By Roberto Scatena (auth.), Roberto Scatena, Alvaro Mordente, Bruno Giardina (eds.)

In contemporary years, melanoma stem cells were famous as very important part in carcinogenesis they usually appear to shape the foundation of many (if now not all) tumor kinds. melanoma stem cells or "cancer phone like stem cells" were remoted from a number of cancers of other beginning (blood, breast, mind, pores and skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). melanoma stem cells - infrequent cells with indefinite proliferative power that force the formation and development of tumours- appear to express interesting relationships with physiological stem cells. in particular, those melanoma cells convey major similarities within the mechanisms that keep an eye on self-renewal of ordinary stem cells. additionally, tumour cells may possibly without delay come up from basic stem cells. additional, the mobile biology of melanoma stem cells exhibit loads of similarities with basic stem cells.

Show description

Read or Download Advances in Cancer Stem Cell Biology PDF

Best cancer books

How To Kill Cancer Cells: Make Your Body Healthy Now

Natalie Mitchell’s Amazon top vendor moment e-book “How To Kill melanoma Cells” units out transparent directions for readers to create a physically atmosphere within which melanoma cells can't thrive. all people has melanoma cells and with the clinical expertise to be had these days medical professionals can in simple terms diagnose melanoma sickness while humans have already got constructed BILLIONS of lively melanoma cells of their physique.

Cancer Incidence in Five Continents: Volume IX (IARC Scientific Publication No. 160)

It really is tricky to estimate the variety of humans around the globe who paintings diligently to gather the information which are provided in melanoma prevalence in 5 Continents. something is apparent: it's a huge quantity. Their mixed paintings is summarized within the pages of this quantity. melanoma occurrence in 5 Continents has develop into the well-known reference resource at the occurrence of melanoma in populations all over the world.

Cancer Caregiving in the United States: Research, Practice, Policy

Regardless of advances in detection and remedy, melanoma is still a resource of soreness and misery to sufferers and of advanced demanding situations to the family taking good care of them. the fashion towards shorter clinic remains particularly has elevated the actual, mental, and monetary burden on caregivers, frequently resulting in hostile results on sufferers.

Extra resources for Advances in Cancer Stem Cell Biology

Example text

Over 700 types of miRNA have been identified so far in the human genome and their respective sequences indicate that each miRNA has the potential to inhibit hundreds of molecules of mRNA. The let-7 was one of the first miRNA to have its expression correlated with inhibition of proliferation and self-renewal of embryonic stem cells. One of the let-7 targets is the transcript of the Hmga2 (high mobility group A2) gene, which encodes a chromatin protein that increases the activity of certain transcription factors.

Differentiated A cell Differentiated B cell ? Niche cell 4RANSFORMATION GENETICEPIGENETIC MUTATIONS ? Cancer A cell Selfrenewal Selfrenewal Cancer stem cell Cancer precursor cell ? Microenvironment (Niche) 2ESISTANTTO CHEMOTHERAPY IRRADIATION Cancer A cell Cancer precursor cell Cancer B cell Cancer B cell 3ENSITIVETOCHEMOTHERAPYIRRADIATION Tumor Fig. 1 Similarity between normal tissue and tumor. Tumors as well as normal tissues are likely to consist of small number of stem cells that have self-renewal capability and multipotentiality, precursor cells that have limited proliferative potency, and differentiated cells.

Cell Stem Cell 1:555–567 Goodell MA, Brose K, Paradis G et al (1996) Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 183:1797–1806 Goodrich LV, Milenkovic L, Higgins KM et al (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277:1109–1113 Gottesman MM, Fojo T, Bates SE (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2:48–58 Haraguchi N, Utsunomiya T, Inoue H et al (2006) Characterization of a side population of cancer cells from human gastrointestinal system.

Download PDF sample

Advances in Cancer Stem Cell Biology by Roberto Scatena (auth.), Roberto Scatena, Alvaro Mordente,
Rated 4.06 of 5 – based on 35 votes