By Lesley-Ann Giddings, David J. Newman
A dialogue of the chemical substances produced by means of organisms dwelling less than severe stipulations that could have strength as medicinal drugs or ends up in novel medicinal drugs for human use. This SpringerBrief offers with bioactive fabrics from terrestrial extremophiles.
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Additional info for Bioactive Compounds from Terrestrial Extremophiles
5, increased salt concentrations in some alkaliphile cultures were considered to be deleterious. On the other hand, lower salt concentrations promote cell lysis. To counterbalance external osmotic pressure, halophiles maintain their turgor by accumulating inorganic ions, such as potassium chloride, in the cytosol such that their internal salt concentration is always comparable to that of their external environment (Pflüger and Müller 2004). Osmolytes or organic molecules are also produced to increase turgor pressure, while salt is eliminated from the cytosol.
YIM 80133 (Li et al. 2007). 5 production media. Griseusin D 101 has a naphthoquinone core with a fused spiroacetal ring system (Tsuji et al. 1976). 52 and 44 µM, respectively. Interestingly, other cytotoxic griseusin derivatives were later identified from alkaliphilic Nocardiopsis species obtained from polluted Chinese soil. Similar to the work done by Stierle et al. on bioprospecting of the Berkeley Pit, He and coworkers screened microorganisms isolated from the alkaline soil of the Datun tin mine tailings in Yunnan province, China, for new metabolites (He et al.
2004) 40 Bioactive Compounds from Terrestrial Extremophiles 5 Alkaliphiles 41 genomic sequencing (Foti et al. 2008; Siddaramappa et al. 2012; Takami et al. 2000; Keshri et al. 2013) of alkaliphiles from different environments have revealed diverse and novel taxon and genes, many of which are unexplored sources of new chemical entities. 6 Halophiles Extreme halophiles are microorganisms that grow in environments with 15 % (w/v) salt to saturation, which are concentrations considered to be hostile to most organisms.
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