By Georges Mathé MD (auth.)
I want to thank all my co-workers who've collaborated with me, from 1963 earlier, in organic and medical learn within the box of melanoma lively immunotherapy, of its immuno prevention and immunorestoration. they're going to frequently be quoted during this booklet. i'm rather thankful to people who have helped me to put in writing it by means of reviewing a few chapters: D. BELPOMME, J. F. DOR~, IRENE FLORENTIN, A. GOUTNER, I. J. Hm, R. HUCHET and MARIE-CHRISTINE SIMMLER. I additionally thank NICOLE VRIZ, MARIE-CLAUDE SCHNEIDER, FENELLARIsELEY and M. JUVET for his or her keen and effective co-operation within the preperation of the manuscript. i'm eventually thankful to all authors of books or articles who licensed me to breed their figures or tables. Paris, April 1976 G. MAT~ Contents bankruptcy 1. creation and Definitions 1 bankruptcy 2. organic foundation: Tumour linked Antigens, the Immune equipment and Its Behaviour bearing on melanoma Cells five 2. 1. Tumour-Associated Antigens five 2. 2. The Immune equipment 19 2. 2. 1. Humoral Mediated Immunity and telephone Mediated Immunity 19 2. 2. 2. T- and B-Lymphocyte and Monocyte Differen tiation 22 2. 2. three. T-Lymphocyte features 25 2. 2. four. B-Lymphocyte services 30 2. 2. five. Macrophage services 31 2. 2. 6. K-Cell functionality 32 2. three. The Immune equipment and melanoma Cells 33 2. three. 1. Mechanisms concerned about Tumour telephone Rejec tion 33 2. three. 1. 1. In vivo facts for Tumour Immunity 33 2. three. 1. 2.
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Extra info for Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration
If some of these immune reactions lead to tumour cell destruction, the others result in tumour protection against the immune aggression mediated by the former. One important step has been the discovery that humoral factors may interfere with cell-mediated immunity. These factors were called blocking factors because they could specifically stop immune lymphocytes from destroying 49 tumour cells in vitro. More recent findings suggest that cells with immunosuppressive functions could be activated during tumour development.
K-cells appear as fully capable effector cells in the microcytotoxicity assay and probably in the colony-inhibition test. In such systems, where the lymphoid cells from tumour-bearing animals are cultivated with tumour cells, the cytotoxic reaction could be based on the presence of immune B-cells secreting antibody which binds specifically to the tumour cells. , 1974) • In the MSV-induced tumour syste~K-cell activity, as well as cytotoxic T-Iymphocyte activity, both measured in the microcytotoxicity assay, are detectable just prior to tumour development, are depressed at peak tumour size and emerge just as the tumour begins to regress.
These are the different components of the immune machinery; a summary of their respective immunological functions follows. 3. , 1966) with pyrininophylic cytoplasm and called immunoblasts by DAMESHEK (1963). 25 Fig. 11. Blood or lymphoid tissue mononuclear cells at scanning electron microscopy. 1. Thymus cell, 2. Bursa of Fabricius cell, 3. Smooth blood lymphocyte, 4. Poorly villous blood lymphocyte, 5. Averagely villous blood lymphocyte, 7. Thymus-dependent immunoblast, B. and 9. Other types of immunoblasts, 10, Plasma cell, 11.
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