By F. M. Muggia, J. Henney, V. DeVita Jr. (auth.), Professor Georges Mathé, Professor Franco M. Muggia (eds.)

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Testicular germ cell tumors are now curable, even in advanced stages [30]. Combination chemotherapy drug regimens, such as that with cisplatinum, vinblastine (VLB), and bleomycin [17], have made a major impact on survival of patients with testicular germ cell tumors, because these regimens can induce a high percentage of 22 G. Bonadonna et al. durable complete remissions, particularly in the absence of minimal advanced disease. The role of combined-modality therapy (chemotherapy and reductive surgery) needs to be further defined.

Figure 2 shows that MTX affects the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) by inhibiting the dihydrofolate reductase. Therefore, if exogeneous tritium-labeled deoxyuridine (dUR) is offered to MTX-treated cells, its incorporation into the DNA is reduced. Thus, the effect of MTX can be monitored biochemically [10, 15]. As a consequence of decreased production of thymidine triphosphate (dTTP) via the de novo pathway, the normal feedback inhibition of the thymidine kinase reaction is released.

24] No. of cases Research group Table 9. Current adjuvant results in colorectal cancer ... e:.. (l> po 5 o 0.. ::: po to o Q tv 0 Adjuvant Therapies of Postsurgical Minimal Residual Disease 21 Table 10. Recent results of adjuvant therapy in totally resected malignant gliomas Author or group No. of Postoperative therapy· patients SOLERO et al. [45] 102 RT + BCNU or CCNU Improved survival after RT + CCNU WALKER and STRIKE [51] 326 Radiotherapy + BCNU + MP ± PCZ ; additional corticosteroid No difference in survival in the four treatment groups EORTC [25] 81 93 RT ± CCNU RT ± VM 26 + CCNU CCNU did not affect RFS; no improvement of early RFS after VM 26 + CCNU RT + BCNU RT + CCNU No difference in survival between the two groups PAOLETTI et al.

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Cancer Chemo- and Immunopharmacology: 1. Chemopharmacology by F. M. Muggia, J. Henney, V. DeVita Jr. (auth.), Professor
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