By Beverly A. Teicher

Major specialists summarize and synthesize the most recent discoveries about the alterations that ensue in tumor cells as they improve resistance to anticancer medicines, and recommend new methods to fighting and overcoming it. The authors evaluation physiological resistance established upon tumor structure, mobile resistance in response to drug delivery, epigenetic alterations that neutralize or skip drug cytotoxicity, and genetic alterations that regulate drug aim molecules via lowering or doing away with drug binding and efficacy. Highlights comprise new insights into resistance to antiangiogenic remedies, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the advance of greater treatments. There also are new findings on tumor immune get away mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Show description

Read or Download Cancer Drug Resistance (Cancer Drug Discovery and Development) PDF

Best anatomy books

Human: The Science Behind What Makes Your Brain Unique

What occurred alongside the evolutionary path that made people so distinctive? In his available kind, Michael Gazzaniga pinpoints the swap that made us considering, sentient people diversified from our predecessors. He explores what makes human brains unique, the significance of language and paintings in defining the human , the character of human realization, or even synthetic intelligence.

Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation Part A: Mammalian Blood Coagulation Factors and Inhibitors

The seriously acclaimed laboratory average, tools in Enzymology, is likely one of the such a lot hugely revered courses within the box of biochemistry. on the grounds that 1955, every one quantity has been eagerly awaited, often consulted, and praised via researchers and reviewers alike. The sequence comprises a lot fabric nonetheless suitable today--truly a necessary book for researchers in all fields of lifestyles sciences

Imaging Anatomy of the Human Spine: A Comprehensive Atlas Including Adjacent Structures

" An Atlas for the twenty first Century the main designated, state-of-the-art photographs of standard spinal anatomy to be had at the present time are the center-piece of this miraculous atlas for clinicians, trainees, and scholars within the neurologically-based clinical specialties. really an ìatlas for the twenty first century,î this entire visible reference offers a close assessment of spinal anatomy received by utilizing a number of imaging modalities and complex suggestions that permit visualization of constructions impossible with traditional MRI or CT.

Additional info for Cancer Drug Resistance (Cancer Drug Discovery and Development)

Sample text

The results suggest that successful therapies should selectively target HIF-1 and/or its downstream target genes, such as VEGF, in order to break this cycle of interdependency. ACKNOWLEDGMENTS This work was supported by grants from the NCI (CA40355) and the Duke SPORE for breast cancer. The authors appreciate the editorial review of this manuscript by Catherine Sullivan and the confocal image of tumor microvascular intussusception provided by Matthew Dreher for Fig. 3. REFERENCES 1. Kraus RM, Stallings HW III, Yeager RC, Gavin, TP.

Dewhirst MW, Ong ET, Braun RD, et al. Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. Br J Cancer 1999; 79:1717–1722. 57. Secomb TW, Hsu R, Braun RD, Ross JR, Gross JF, Dewhirst MW. Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. Adv Exp Med Biol 1998; 454:629–634. 58. Dewhirst MW, Secomb TW, Ong ET, Hsu R, Gross JF. Determination of local oxygen consumption rates in tumors. Cancer Res 1994; 54:3333–3336.

The relationship between extracellular pH (pHe) and intracellular pH (pHi) in human, rat and mouse tumors in situ. Both pHe and pHi in the same tumors were determined with magnetic resonance imaging/magnetic resonance spectroscopy method. Data reported by ref. 6 were used to construct this figure. and rat tumors determined with MRS/magnetic resonance imaging method and reviewed by Gilles (6). It can be seen that the pHi values are higher than the pHe values in the same tumors in all tumors studied.

Download PDF sample

Cancer Drug Resistance (Cancer Drug Discovery and by Beverly A. Teicher
Rated 4.58 of 5 – based on 28 votes