By Usha Kasid, Robert Clarke
This quantity is a priceless and well timed source for a vast viewers with pursuits in simple and translational melanoma biology, melanoma drug improvement, in addition to within the perform of custom-made oncology. Written within the hugely winning tools in Molecular Biology sequence structure, chapters comprise introductions to their respective themes, lists of the required fabrics and reagents, step by step, effortlessly reproducible laboratory protocols, and pointers on troubleshooting and fending off recognized pitfalls.
Authoritative and state-of-the-art, Cancer Gene Networks goals to make sure winning ends up in the additional examine of this evolving and very important box. finally those efforts will advisor improvement of transformative options for melanoma prognosis and treatment.
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The cancer-specific expression of ANXA7-GTPase, coupled with its importance in regulating cell death, cell motility, and invasion, makes it a useful diagnostic marker of cancer and a potential target for cancer treatment. Recently, emerging evidence suggests that ANXA7-GTPase is a critical factor associated with the metastatic state of several cancers and can be used as a risk biomarker for HER2 negative breast cancer patients. Cross talk between ANXA7, PTEN, and EGFR leads to constitutive activation of PI3K-AKT signaling, a central pathway of tumor cell survival and proliferation.
Technol Rev 104:54–60 6. Ito T, Ando H, Suzuki T et al (2010) Identification of a primary target of thalidomide teratogenicity. Science 327:1345–1350 7. Geoghegan KF, Johnson DS (2010) Chemical proteomic technologies for drug target identification. Annu Rep Med Chem 45:345–360 8. Niphakis MJ, Cravatt BF (2014) Enzyme inhibitor discovery by activity-based protein profiling. Annu Rev Biochem 83:341–377 9. Cravatt BF, Wright AT, Kozarich JW (2008) Activity-based protein profiling: from enzyme chemistry to proteomic chemistry.
Because the murine Anxa7 locus, like its syntenic human counterpart, is fragile, mice that were heterozygous for inactivation of ANXA7 developed mostly lymphosarcoma of the thymus, spontaneously due to genomic instability. In general, the frequency of spontaneous tumor occurrence is in the range of 20–30 %, becoming more accentuated with advancing age [52]. ” Increased tumor incidence in the Anxa7-challenged mice was associated with the gender-related cell growth anomalies indicating possible defects in sex hormone synthesis or actions.