By Gerard I. Evan, Elizabeth H. Harrington, Nicola J. McCarthy (auth.), Enrico Mihich, David Housman (eds.)

The built-in keep an eye on of telephone Proliferation and cellphone Viability; G.I.Evan, et al. keep an eye on of Invasive phone progress via the MET family members Oncogenes; F. Galimi, P.M. Comoglio. Src kinfolk Kinases and the mobilephone Cycle; S.A. Courtneidge. p16 kinfolk Inhibitors of Cyclin-Dependent Kinases; Y. Li, et al. p53-Mediated Apoptosis: Regulatory and Mechanistic points; Y. Haupt, et al. The Molecular Genetics of Wilms Tumor; J. Pelletier, et al. HTLV-1 Tax: A Paradigm for the way a unmarried Auxiliary issue Can control the Expression of Viral and mobile Genes; G. Perini, M.R. Green. CREM: Transcriptional Pacemaker of the cAMP reaction; J.S. Lee, et al. MADS-domain transcription issue and Their accent Proteins (TCFs): Nuclear pursuits for development keep an eye on indications; M.A. Cahill, et al. Retinoblastoma Protein, Gene Expression, and telephone Cycle keep watch over; J.C. Azizkhan, et al. Cyclin A-kinase Binding to and rules of the functionality of a Growth-Promoting Transcription issue; W. Krek, et al. Homeostatic Mechanisms Governing the pass hase as outlined through the Gas Genes; C. Schneider, et al. The TEL Gene and Human Leukemias; T.R. Golub, et al. Characterization of the TCLI Gene and Its Involvement in T-Cell Malignancies; L. Virgilio, et al. three extra Articles. Index.

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Coordination of cell growth, movement and matrix invasion occurs not only in physiological events but also in the progression of cancer cells towards malignancy. , 1994), induce expression of uP A and its receptor as an early event in the course of the mitogenic response (reviewed in Saksela and Rifkin, 1988). , 1991). The induction of uP A is therefore an indirect mechanism through which HGF promotes cell invasiveness. STRUCTURE, BIOSYNTHESIS AND SUBCELLULAR DISTRIBUTION OF THE HGF RECEPTOR The HGF receptor is the tyrosine kinase encoded by the MET proto-oncogene.

269, 1815-1820. , Magni, M. M. (1991) Intracellular calcium regulates the tyrosine kinase receptor encoded by the MET oncogene. J. BioI. Chern. 266, 16098-16104. , Follenzi. J. M. (1994). Ron is a heterodimeric tyrosine kinase receptor activated by the HGF-homolog MSP. , 13, 3524--3532. , and Furlong, R. (1989). Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interaction and movement. Proc. Natl. Acad. Sci. USA 86, 5844--5848. , Rosa, C. M. (I 989b) Biosynthesis of the protein encoded by the c-METproto-oncogene.

1993a). ,1992). , 1994). , 1992). , 1990). , 1989). ,1991). The maturation of pro-HGF to functional HGF is a crucial point in the physiology of the factor. ,1993). , 1995). In a standard catalytic reaction, given enough time, virtually all the substrate is processed and the total yield of product is independent from the concentration of enzyme. The reaction is only limited by the initial substrate concentration. On the contrary, for uPA and HGF the limiting factor is the amount of enzyme and not the amount of substrate.

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Cancer Genes: Functional Aspects by Gerard I. Evan, Elizabeth H. Harrington, Nicola J. McCarthy
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