By Ivan Damjanov MD, PhD (auth.), Ivan Damjanov MD, PhD, Fang Fan MD, PhD (eds.)

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The nuclei are still elongated, and even though they may have slightly irregular contours, they are still polarized. Nuclear stratification resembling the changes in tubular adenomas of the colon may extend all the way to the surface of the lesions. Nucleoli may be seen, but are not prominent. • Barrett esophagus, high-grade dysplasia. Loss of surface maturation is the most important feature of this lesion. The glands appear crowded in the surface and basal parts of the epithelium, and the stroma is barely evident.

Diagnostic Histopathology of Tumors. 2nd edition. London: Churchill-Livingstone; 2000. Weidner N, Cote RJ, Suster S, Weiss LM, eds. Modern Surgical Pathology. Philadelphia: Saunders, Elsevier; 2003. Articles 1. Yesner R. The dynamic histopathologic spectrum of lung cancer. Yale J Biol Med. 1981;54:447–456. 2. Dunnill MS, Gatter KC. Cellular heterogeneity in lung cancer. Histopathology. 1986;10:461–475. 3. Travis WD. Pathology of lung cancer. Clin Chest Med. 2002; 23:65–81. 6 Tumors of the Thymus Saul Suster and Cesar Moran Introduction Primary thymic epithelial neoplasms represent the most common type of tumors of the anterior mediastinum.

3. Wiernik G, Millard PR, Haybittle JL. The predictive value of histological classification into degrees of differentiation of squamous cell carcinoma of the larynx and hypopharynx compared with the survival of patients. Histopathology. 1991; 19:411–417. 4. Janot F, Klijanienko J, Russo A, et al. Prognostic value of clinicopathologic parameters in head and neck squamous carcinoma: a prospective analysis. Br J Cancer. 1996;73:531–538. 5. Chiesa F, Mauri S, Tradati N, et al. Surfing prognostic factors in head and neck cancer at the Millennium.

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Cancer Grading Manual by Ivan Damjanov MD, PhD (auth.), Ivan Damjanov MD, PhD, Fang
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