By Stanley Shostak (Ed.)
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Additional info for Cancer Stem Cells Theories and Practice
The most recent results in the less advanced field of reprogramming seem to indicate that, also in this experimentally-induced “progression to pluripotency” (in analogy to tumoral progression) exactly as it happens in tumour progression, the elimination of the DNA damage control checkpoint tremendously increases the efficiency of the reprogramming process. , 2008) . However, this enhanced efficiency is achieved at the price of a much higher genetic instability, and the iPSCs generated in this way carry many genetic aberrations of different types.
2009) can generate CSCs when they are introduced into target cells that were already committed. , 2006).
2006). The role of epigenetic alterations in tumour origin and progression is well known and it has been comprehensively reviewed elsewhere (Esteller, 2007, 2008; Esteller and Herman, 2002). All epigenetic marks become altered in tumours, leading to changes in gene expression. These changes have been very well described to affect many specific genes in charge of controlling cellular functions, which therefore become altered in cancer. But these changes are in fact global and affect the whole cellular identity.
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