By Marek Los, Henning Walczak
The amount bargains perception into the foremost study themes that contain caspases. best specialists from a variety of components of biology and drugs have compiled this quantity in order that either the beginner and the pro will use this because the major reference for caspases for years yet to come. The reader will know about the position of caspases in apoptosis signaling, irritation and melanoma remedy whereas being up to date at the method used to check caspases and the efforts of pharmaceutical learn in focusing on caspases.
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Additional info for Caspases: Their Role in Cell Death and Cell Survival (Molecular Biology Intelligence Unit)
160,161 Several cellular and viral encoded caspase inhibitors have been discovered. , vaccinia virus) encode the caspase inhibitor CrmA (cytokine response modifier A) that structurally belongs to the serpin (serine protease inhibitor) type of protease inhibitors. 163,164 Like serpins, CrmA acts as a pseudosubstrate with the caspase recognition site LVAD, 22 Caspases—Their Role in Cell Death and Cell Survival Figure 8. Schematic representation of the different functional groups in peptide-based caspase inhibitors.
0 The dissociation constants (Ki) of the viral inhibitors CrmA and p35 for a given caspase have been determined using recombinant inhibitors and caspases in fluorometric assays. (adapted from refs. 165,166,210). Phylogenetic Analysis of the Caspases Alignment of different proteins of the same family can provide information on their phylogenetic relationship and in some cases indicate which family members execute similar functions. The caspase phylogenetic tree we present in Figure 9 is based on the amino acid sequence containing the p20 and p10 units and, when present, the short interdomain between them.
Activation of caspase-12 by calpain in apoptosis. Cell Biol 2000; 150:887-94. 48. Walker NP, Talanian RV, Brady KD et al. Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer. Cell 1994; 78:343-52. 49. Wilson KP, Black JA, Thomson JA et al. Structure and mechanism of interleukin-1 beta converting enzyme. Nature 1994; 370:270-5. 50. Rotonda J, Nicholson DW, Fazil KM et al. The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.
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