By Hari G. Garg, Robert J. Linhardt, Charles A. Hales
The chemistry, biochemistry and pharmacology of heparin and heparan sulfate were and stay a tremendous medical project - heparin and its by-product stay very important medicines in medical perform. Chemistry and Biology of Heparin and Heparan Sulfate offers readers with an perception into the chemistry, biology and scientific purposes of heparin and heparan sulfate and examines their functionality in quite a few physiological and pathological stipulations. delivering a wealth of beneficial info, no different tome covers the range of subject matters within the box. scholars, medical professionals, chemists, biochemists, and examine scientists will locate this publication a useful resource for updating their present wisdom of advancements during this region. * Comprehensively stories all elements of heparin and heparan sulfate study* Uniquely describes the chemistry, biology and scientific program of heparins and heparan sulfates in a single paintings* offers a useful resource of data of present advancements for chemists, biochemists, doctors, researchers, scholars and practitioners
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Extra resources for Chemistry and Biology of Heparin and Heparan Sulfate
Maccarana M, Casu B, Lindahl U. Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor. J Biol Chem 1993; 268:23898-23905. Pye DA, Vives RR, Hyde P, Gallagher JT. Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features : differential requirements for the modulation of FGF-1 and FGF-2. Glycobiology 2000; 10:1183-1192. 26 89. 90. 91. 92. 93. 94. 95. 96. 97. 98. 99. 100. 101. B. Casu Ishihara M.
J Biol Chem 2001; 276:30744-30752. Scholefield Z, Yates EA, Wayne G, Amour A, McDowell W, Turnbull JE. Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer [3-secretase. J Cell Biol 2003; 163:97-107. van der Born J, Gunnarsson K, Bakker MA, Kjell6n L, Kusche-Gullberg M, Maccarana M, Berden JH, Lindahl U. Presence of N-unsubstituted units in native heparan sulfate revealed by a monoclonal antibody. J Biol Chem 1995; 270:31303-31309. Norgrad-Sumnicht K, Varki A. Endothelial heparan sulfate proteoglycans that bind to L-selectins have glucosamine residues with unsubstituted amino groups.
Collagen XVIII Collagen XVIII is a heparan sulfate containing proteoglycan containing eight potential glycosaminoglycan glycosylation sites (125) localized in endothelial and epithelial basement membranes. A C-terminal peptide of collagen XVIII showed both anti-angiogenic and anti-tumor properties (126, 127). These discoveries have brought much research attention to collagen type XVIII. However, the angiogenic effects are limited to blood vessel development in only the eye, as shown through collagen XVIII null mice (128).
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