By Anthony B. Ward, Michael P. Barnes

Botulinum pollutants now play a really major function within the administration of a large choice of health conditions; from complications to hypersalivation, and from spasticity to sweating. during this booklet, a robust, foreign group of specialists define the elemental neurochemistry of botulinum pollution and chart the development of the drug from laboratory to hospital. Then person chapters summarize their use for the most medical symptoms within the context of alternative on hand remedies. This booklet might be of curiosity to neuroscientists and working towards clinicians operating in a variety of specialities, from neurology and dermatology to pediatrics, cosmetic surgery and rehabilitation medication.

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L. (2004). Identification of the major steps in botulinum toxin action. Ann. Rev. Pharmacol. , 44, 167À93. 14. , Matteoli, M. and Montecucco, C. (2000). Neurotoxins affecting neuroexocytosis. Physiol. , 80, 717À66. 15. Dolly, J. , Lande, S. and Wray, D. (1987). The effects of in vitro application of purified botulinum neurotoxin at mouse motor nerve terminals. J. Physiol. ), 386, 475À84. 23 Mechanistic basis for the therapeutic effectiveness 16. , Burnstock, G. and Dolly, J. O. (1982). The effects of purified botulinum neurotoxin type A on cholinergic, adrenergic and non-adrenergic, atropine-resistant autonomic neuromuscular transmission.

And Dolly, J. O. (1987). Selective location of acceptors for botulinum neurotoxin A on central and peripheral nerves. Neuroscience, 23, 767À79. 24 J. O. Dolly and G. Lawrence 29. Black, J. D. and Dolly, J. O. (1986). Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis. J. , 103, 535À44. 30. Hughes, R. and Whaler, B. C. (1962). Influence of nerve-ending activity and of drugs on the rate of paralysis of rat diaphragm preparations by Cl.

Abstr. 9th Nat. Mtg. Bayliss & Starling Soc. 38. Lawrence, G. , Weller, U. and Dolly, J. O. (1994). Botulinum A and the light chain of tetanus toxins inhibit distinct stages of MgATP-dependent catecholamine exocytosis from permeabilised chromaffin cells. Eur. J. , 222, 325À33. 39. Welch, M. , Purkiss, J. R. and Foster, K. A. (2000). Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins. Toxicon, 38, 245À58. 40. , Kemmer, T. P. and Gratzl, M. (1992). Amylase release from streptolysin O-permeabilized pancreatic acinar cells.

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Clinical Uses of Botulinum Toxins by Anthony B. Ward, Michael P. Barnes
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