By M. Gignoux, A. Roussel, B. Paillot, M. Gillet, P. Schlag, O. Dalesio, M. Buyse, N. Duez (auth.), Professor Dr. Peter Schlag, Dr. Peter Hohenberger, Priv. Doz. Dr. Urs Metzger (eds.)

Modern surgical oncology is characterised through multimodal treatment. lately a variety of healing methods of pre-, peri-, intra-and postoperative therapy were in­ vestigated in regards to their use together with surgi­ cal intervention. It now could be time to investigate and to outline the kingdom of our wisdom. For tumors of the gastrointestinal tract there are a number of encouraging healing techniques, akin to preop­ erative chemotherapy in esophageal and perioperative chemotherapy in colon melanoma. For a few exact tumors, like anal carcinoma, we've got sincerely outlined mixed cures which even now needs to be considered as ordinary therapy. it's also time to illustrate the result of numerous clini­ cal stories which have been performed in the previous few years that mixed surgical efforts with pre- or postinter­ ventional chemotherapy or radiotherapy. it's important to guage no matter if those trials give a contribution to development in onco­ logical remedy. The editors of this quantity - surgeons on the college hospitals of Heidelberg and Zurich - has to be given the mer­ it of attaining those pursuits. It was once specifically acceptable for the dep. of surgical procedure in Heidelberg, in shut coopera­ tion with the great melanoma middle Heidelberg/ Mannheim, to arrange a evaluation of our current wisdom of surgical oncology because it is within the culture of trying to mix diversified healing methods to melanoma therapy.

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Verhaege M, Rohart J, Adenis L, Demaille A, Lequint A, Vankemel B, Delloitte M (1971) Possibilites et resultats de la radiotherapie dans les cancers de I'oesophage (a propos de 300 cas en 10 ans). Presse Med 79: 236 4. Pierquin B, Wanbersie A, Tubiana M (1966) Cancer of thoracic oesophagus: two series of patients treated by 22 mv betatron. Br J Radiol 39: 189-192 5. Marcial VA, Tome JM, Ubinas J, Bosh A, Correa IN (1966) Esophageal cancer: the role of radiation therapy. Radiology 87: 231-239 6.

A Cox proportional-hazard model was adjusted in order to test the relative importance of the variables for the duration of survival. Using a step-down procedure, factors adding no significant discrimination were excluded from the model. Two variables were retained in the model, in decreasing order of importance: the weight loss and the performance status. 034, Fig. 3). 08). However, no difference was seen in the survival. Comparisons by treatment in the group of patients with more than 10% weight loss showed no difference for any of the end points.

Thirty-three patients completed the treatment program and were evaluable. They included 30 squamous cell carcinomas, two anaplastic (squamous cell) carcinomas, and one adenocarcinoma. The roentgenographic filling defect was up to 5 cm long in five patients and 5-8 cm long in 20, and in eight the length of the esophagus segment involved in the tumor exceeded 8 cm. A weight loss exceeding 10% of body weight was recorded in 20 patients; in the other 13 cases the weight loss was less than 10% (Table 4).

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Combined Modality Therapy of Gastrointestinal Tract Cancer by M. Gignoux, A. Roussel, B. Paillot, M. Gillet, P. Schlag, O.
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