By Michael B. Sporn (auth.), Michael B. Sporn (eds.)

It is now obvious that numerous fields of research are converging upon one another because the target of discovering a realistic approach to hinder melanoma is pursued. the current monograph represents the efforts of an interdisciplinary ESO job strength that used to be convened to evaluate interactions of peptide progress components and steroid-like molecules within the prevention of melanoma. all the contributors within the activity strength represents a differentscientific self-discipline, and the monogrph is meant to be a synthesis in their various ways to the typical challenge of melanoma prevention. it really is was hoping that the reader will locate this monograph to be of use within the assessment of either preclinical and medical techniques to the main concerns that face us in chemoprevention. it's transparent that prevention of melanoma is an idea whose time has come, and the matter now could be to enforce the simplest techniques towards attaining the specified goals.

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The suppression of breast cancer in the experimental animal by pregnancy was described many years ago [16], and endocrine influence,s that suppress the development of human breast cancer are well established [17]. The important role of the immune system as an innate protective mechanism against carcinogenesis has been discussed at length by others and will not be considered here. Important as all innate protective mechanisms may be for suppression of potentially carcinogenic lesions, they are not adequate in themselves for elimination of the epithelial cancer problem in humans.

The binding region between nucleotides -80 and -100 is conserved in the 5' flanking regions of at least 5 different casein genes from mouse, rat and cow. A second binding site with a lower binding affinity is located between -130 and -150. This sequence conservation in different species is suggestive for a functional role for this DNA motif in the transcriptional regulation of the promoter. This was supported by the tissue specificity of MGF activity. MGF was assayed in extracts from various mouse tissues and could only be found in mammary gland cells.

Proc Natl Acad Sci USA 1990 (87):9118-9122 29 Schonenberger CA, Zuk A, Groner B, Jones Wand Andres AC: Induction of the endogenous whey acidic protein (Wap) gene and a Wap-myc hybrid gene in primary murine mammary organoids. Develop Bioi 1990 (139):327-337 30 Yu-Lee LY: Prolactin stimulates transcription of growth related genes in Nb-2 Tlymphoma cells. Mol Cell Bioi 1990 (68):21-28 31 Yu-Lee LY, Hrachovy JA, Stevens AM and Schwarz LA: Interferon regulatory factor 1 is an immediate early gene under the transcriptional regulation by prolactin in Nb-2 T cells.

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Control of Growth Factors and Prevention of Cancer by Michael B. Sporn (auth.), Michael B. Sporn (eds.)
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