By Riekelt H. Houtkooper (eds.)

The sirtuin family members of proteins (SIRT1-7) got loads of cognizance in recent times as they function metabolic sensors that regulate not just metabolism, but in addition getting older and lifespan legislation. As such, sirtuins are robust goals for the remedy of age-related metabolic ailments, together with weight problems, diabetes, and melanoma. certainly, many learn teams in addition to pharmaceutical businesses came upon foodstuff elements and/or medications that focus on the sirtuins and supply major wellbeing and fitness advantages. This e-book makes a speciality of numerous points of sirtuin biology, from simple biochemistry, through molecular functionality, to its function in (fighting) human disease.

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2009) FOXP3 van Loosdregt et al. (2010) HSF1 Ahn et al. (2008) HNF4 Yang et al. (2009) HIF2alpha Dioum et al. (2009) c-FOS Zhang et al. (2010) c-JUN Zhang et al. (2010) SREBP Ponugoti et al. (2010) and Walker et al. 1 (continued) Protein References XPA Fan and Luo (2010) APEX1 Yamamori et al. (2010) TIP60 Peng et al. (2012) and Wang and Chen (2010) Tau Min et al. (2010) NRF2 Kawai et al. (2011) AKT Sundaresan et al. (2011) PDK1 Sundaresan et al. (2011) CIITA Wu et al. (2011) DNMT1 Peng et al. (2011b) NICD Guarani et al.

1937). Furthermore, NA is effective in the treatment of hyperlipidemia, despite causing undesired flushing as an adverse effect (Houtkooper et al. 2010).  Indeed, supplementing these compounds to the diet of mice leads to an overall improved metabolic profile. NR supplementation attenuated the body weight gain on a high-fat diet, and thereby prevents the development of insulin resistance (Canto et al. 2012). Furthermore, these mice are resistant to cold and perform better on a treadmill (Canto et al.

Nature 430:686–689 Yamane K, Kinsella TJ (2005) CK2 Inhibits apoptosis and changes its cellular localization following ionizing radiation. Cancer Res 65:4362–4367 Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A et al (2007a) Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130:1095–1107 1 Biochemistry and Enzymology of Sirtuins 27 Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, Bhalla K, Bai W (2007b) SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress.

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Sirtuins by Riekelt H. Houtkooper (eds.)
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